P009 The effects of low-dose morphine on sleep and breathlessness in chronic obstructive pulmonary disease

Abstract Introduction Low-dose morphine is prescribed for refractory breathlessness in chronic obstructive pulmonary disease (COPD). Preliminary investigations suggest improved perceived sleep quality, although concerns exist regarding opioid-induced sedation. This study assessed the effects of on subjective quality and alertness, potential links between breathlessness. Methods Analysis questionnaire data at baseline after one week low-dose slow-release versus placebo according to a double-blind randomised controlled design was performed. Participants were placebo, 8mg or 16mg/day oral (before further dose escalation). Epworth Sleepiness Scale (ESS), Karolinska Sleep Score (KSS), Leeds Evaluation Questionnaire (LSEQ) severity scores assessed. Dose measures via linear regression (including measures). Drug relationship mixed models with random three-way interaction measures, dose, visit. Results 156 patients as follows: 8mg, n=55; 16mg, n=51; n=50. Overall, there neutral effect ESS, KSS, LSEQ (all p>0.05). Morphine did not modify Discussion Despite safety concerns, negatively impact daytime alertness measures. There no clear morphine’s next-day perception. Objective assessing are required explore people COPD.